Allergan buying Kythera, developer of double chin treatment

July 22nd, 2015

Botox maker Allergan buying Kythera, developer of double chin treatment

Already hoping to erase your wrinkles, Allergan now wants to do away with double chins.

The Ireland-based drug company, seller of Botox anti-wrinkle injections, agreed Wednesday to pay $2.1 billion in cash and stock for Kythera Biopharmaceuticals Inc.

Kythera, based in Westlake Village, is rolling out its first major product: a new injectable, fat-destroying drug called Kybella that reduces double chins, technically called submental fullness.

Kybella was approved by the U.S. Food and Drug Administration in April, and Kythera also hopes to sell the drug in Canada, Australia, Switzerland and other foreign countries.

Allergan said Kythera would broaden its product line in the multibillion-dollar market for “facial aesthetics,” or what some might simply call people’s vanity.

“When you talk to physicians … they say this is a huge opportunity for them to really help patients feel better about their face, and it can potentially attract more patients,” Allergan Chief Executive Brent Saunders told analysts on a conference call Wednesday.

Allergan hopes that’s especially true for men, who currently account for only 12% to 13% of patients for facial treatments, he said.

Allergan, based in Dublin, agreed to pay $75 a share for Kythera, a 24% premium above Kythera’s closing price Tuesday.

In response, Kythera shares soared $13.39, or 22%, to $74.11 on Wednesday. Allergan shares gained 77 cents to $298.79.

Kythera previously suggested that the double-chin drug could generate $500 million a year in sales. Botox generates more than $2 billion in annual sales.


Still, “this deal looks a bit pricey” under the merger’s terms even though Allergan, with its established market channels, “is an ideal commercial organization to take [Kybella] forward,” analyst Ronny Gal of the investment firm Sanford C. Bernstein wrote in a note to clients.

Until this week, Allergan was called Actavis. But Actavis adopted the new name after buying the former Allergan Inc., based in Irvine, for $70 billion in March.

Allergan still has 2,100 employees in Irvine and an additional 300 in Corona. Its global workforce totals 30,000.

Actavis’ offer thwarted a contentious takeover bid for the old Allergan last year by Valeant Pharmaceuticals International Inc., a Canadian company.

Valeant had partnered with hedge fund manager Bill Ackman in the attempted takeover, arguing that Allergan spent too heavily on research, which dragged down profits.

Allergan’s product line also includes Restasis, a prescription drug for chronic dry eye, and Latisse, a prescription drug that creates thicker eyelashes.

Allergan’s decision to buy Kythera “was likely not a hard one as their double-chin treatment Kybella is exactly the type of product that Allergan excels in selling,” analyst Maxim Jacobs at Edison Investment Research wrote in a note to clients.

Allergan CEO Saunders told analysts that the company would ramp up Kybella sales “much faster than Kythera could have on their own given our size and scale.”

Saunders also said that because users of Botox and certain other products “are comfortable with facial injections” they would be “the initial target [market] for Kybella.”

Kythera raised $72.5 million in its 2012 initial public offering. As primarily a clinical-stage, research-and-development firm with just over 100 employees, it has posted losses since then, including a $135.6-million loss last year.

Copyright © 2015, Los Angeles Times


Fat Grafting Widely Used During Facelift Surgery

July 15th, 2015

‘Fat Grafting’ Widely Used During Facelift Surgery

Procedure is helpful for adding volume, roundness to certain areas of the face, experts say

FRIDAY, July 10, 2015 (HealthDay News) — Most U.S. plastic surgeons use a procedure called “fat grafting” to enhance the effects of facelifts, a new study reports.

This technique involves transferring small amounts of fat from one part of a patient’s body to another. The fat is obtained from the belly or thighs through liposuction. The fat is then injected into specific areas of the face to provide more volume.

The researchers surveyed a random sample of members of the American Society of Plastic Surgeons about their use of fat grafting for facelifts. Just over 300 members responded.

The investigators found that 85 percent of the surgeons polled reported using fat grafting during facelifts. Meanwhile, more than 70 percent of the doctors surveyed said they began using fat grafting to the face within the past decade.

Results were published in the July issue of Plastic and Reconstructive Surgery.

Fat was often collected from the belly and injected into the face in tiny amounts — typically no more than a few teaspoons, the researchers said in a journal news release. Fat was often used in the cheeks, which can appear sunken from aging. Fat grafting provides a more rounded appearance to the face, the researchers explained.

Fat grafting was also commonly used below the lower eyelids or in the folds between the nose and the corners of the mouth, according to the research team that was led by Dr. Sammy Sinno, a plastic surgeon at New York University.

Although some injected fat is reabsorbed by the body over time, the surgeons surveyed believed that most of the fat was still in place up to one year following a facelift. Follow-up procedures were also performed to refine the results around four to six months after the initial procedure. The doctors surveyed said their patients were satisfied with their results.

More information

The American Academy of Facial Plastic and Reconstructive Surgery has more about facial fat grafting.

SOURCE: Plastic and Reconstructive Surgery, news release, June 29, 2015

– Mary Elizabeth Dallas

Last Updated: Jul 10, 2015

Copyright © 2015 HealthDay. All rights reserved.


What you Should Know about Rhinoplasty

June 30th, 2015

Rhinoplasty is an excellent treatment for people who are looking to fix their noses. Noses can lose shape or look odd due to a variety of reasons that include injury or birth defects etc.  Rhinoplasty can be used to shape the nose, change the size, improve nose width, position the nose properly, and even position the nostrils appropriately. Plus, rhinoplasty can treat conditions that are caused as a result of an oddly shaped nose, such as poor breathing abilities or poor appearance. However, there are several things to consider before going in for a rhinoplasty procedure.

Things to Know about Rhinoplasty

Before you go in for a rhinoplasty, it is safer to known what to expect. This can help you make a better decision and prepare you for the procedure. Here’s what you should know:

  • Health: Ideally speaking, It is advisable that the patient be in good health in order to enjoy a successful Rhinoplasty. For instance, smoking must be completely avoided before the procedure. In fact, the patient must quit months in advance. Smoking can slow down the healing process by limiting blood flow. Alcohol also has a similar effect and therefore, must be avoided before the procedure.
  • Post-surgery: The results of the surgery take a long time to become evident. Sometimes, it can even take a year to actually notice results. Also, there is bound to be some level of swelling post surgery. Ideally, the doctor would advise you to use cold compress to reduce the swelling. Usually, 85% of the swelling subsides in a month.
  • Risks: There are a few risks that you need to be aware about before going in for the procedure. These risks include bleeding, septum injury, necrosis, anesthesia side effects, infection, irritation and more. However, these risks can be avoided with careful preparation and by choosing the right surgeon.

Interested in learning more about Rhinoplasty? Contact Naples Cosmetic Surgery Center

For more information about Rhinoplasty, contact Naples Cosmetic Surgery Center. We are located in Naples and can be reached directly at 239.348.4357. We look forward to hearing from you soon.

Is Lip Augmentation Right For You?

May 26th, 2015

Pouts are very powerful. If you are unhappy with your pout or feel that you want fuller lips, there are treatments available to help you. These fall in the category of lip augmentation surgery, which is a cosmetic procedure designed to give you larger and fuller lips. It can be performed on both upper and lower lips, or just one of them. Note that, depending on the materials used for augmentation, a temporary or a permanent result can be achieved. Usually, just one procedure is sufficient to get the desired outcome.

How is the Procedure Performed?

  • Approaches: There are several approaches that can be taken to give you fuller lips. They can generally be classified into two categories: injections and implants. When it comes to injections, several options are available. These include collagen, synthetic materials, Dermalogen, Restylane®, Hylaform® and more. It is also possible to use fat from another part of your body to increase the size of your lips. For implants, synthetic options are the most popular.
  • The procedure: Depending on the approach, a topical, local or general anesthetic may be used. Injections generally require only topical anesthetics but implants may require more. The procedure will usually take not more than one hour. Before the procedure, if synthetic materials will be used, you will need to be tested for possible allergic reactions. Then, fillers will be injected directly into your lips. If, on the other hand, you decide to go the route of implants, then incisions will be made on the edges of your lips through which a synthetic material, like Gore-Tex, will be inserted. Then, the incisions will be stitched together, resulting in a permanent increase in the size of your lips.

Are You Interested in Lip Augmentation Surgery? Contact Naples Cosmetic Surgery Center.

To learn more about any of the procedures we offer, contact us today to schedule an appointment. Our offices are located in Naples, and we can be reached at 239-348-4357. We look forward to hearing from you.

Is your skin ready for the summer? Naples Cosmetic Surgery Center helps you prevent skin cancer.

May 20th, 2015

Jane Iredale – THE SKIN CARE MAKEUP supporting you in the fight against skin cancer.  When used regularly in the prescribed manner,
our Skin Cancer Foundation Seal of Recommendation products may help reduce the potential risk of skin cancer due to overexposure to sunlight and serve as an
effective aid in the prevention of sun induced damage to the skin, including and possibly premature aging. Call our office today to find out more @239-348-4357.




Buhbye, Double Chins: FDA Approves Wattle-Reducing Injections

May 12th, 2015

We can freeze our wrinkles, smooth our fine lines and zap away our skin imperfections. But the biggest cosmetic complaint of many — the double chin — has been neglected in the world of noninvasive cosmetic surgery advances. Until now.

An injection called ATX-101, which targets double chins was approved on Wednesday by the U.S. Food and Drug Administration (FDA). ATX-101 consists of deoxycholic acid that’s injected into skin to target and eliminate fat cells under the chin without spreading to surrounding tissue. Its maker, Kythera Biopharmaceuticals Inc., hopes to make the injections available in the back half of 2015.

“This drug is going to be a game changer – no question about it,” Nashville dermatologist, Michael Gold, MD, tells Yahoo Health; Gold participated in clinical studies of the drug. “It worked incredibly well in patients who were treated, as shown by results versus placebo. It’s indicated for the neck, but I won’t be surprised if people use this off-label with other areas of the body, like we saw with Botox,” he adds.

While double chins may be caused by natural genetics, advancing age and weight gain, experts say ATX-101 currently works best on a certain case type. “The ideal candidate is a younger individual with good skin elasticity and a milder double chin — it’s not going to replace a lift yet,” says New York facial plastic surgeon and president-elect of the Facial Plastic Surgery & Reconstructive Surgery Academy(AAFPRS), Edwin Williams, MD.

The full treatment will be a series of injections spaced no less than a month apart. “Many patients experienced meaningful improvement in two to four treatments,” says San Diego dermatologist Sabrina Guillen Fabi, MD, who was a principal investigator in the Phase II clinical trial of the drug, which saw 68.2 percent of patients respond positively, as compared to a 20.5 percent placebo rate.

ATX-101 comes at a time when solutions for double chins and sagging necks are the most searched cosmetic terms among the middle-aged. “In our market research, we found that future interest in pursuing help to change the appearance of body parts drops dramatically after age 44, with the one very big exception of changes to the neck. It’s such a popular topic of conversation, that we just added a discussion forum dedicated to it this year,” says founder and CEO Tom Seery.

Aiding the potential popularity of the new drug is the fact that double chins and excess neck fat are very common complaints brought to cosmetic specialists, and yet nothing outside of surgery currently exists to improve the issue. Gold says that once approval comes, combining the injection with a fractionated ultrasound technology like Ultherapy may bring even more dramatic results – though further clinical studies would have to be done to determine the best protocol.

And while there has been no hint of pricing yet, our experts hypothesize that ATX-101 will be similar to high-end skin tightening treatments on the market, and perhaps cost upwards of $2,000+ per treatment, depending on the severity of the case and the regional area.


The N.Y. Face vs. the L.A. Face: Top Plastic Surgeons Reveal Biggest Differences

May 4th, 2015

This story first appeared in the April 24 issue of The Hollywood Reporter magazine. These days, when it comes to the polarization of New York and Los Angeles, you can look straight at the face. Think Robin Wright versus Meg Ryan, and in a blink of a tautened eye, it’s clear who has “New York face” and who has “L.A. face” among the over-40 female set. According to each city’s most elite skin doctors, what George Orwell said about wearing your true face at 50 never has been less true — particularly for Angelenos. “In New York, my patients want to look like themselves but better,” says New York plastic surgeon Sherrell Aston. “On the West Coast, there’s more of an ‘operated look’: lips too big, noses up too high, more forehead lifts.” New York derm Patricia Wexler agrees. “New York women want their faces to move,” she says, “not that ‘pit bull look’ [in L.A.]: Faces filled artificially are too round and bloated.” Compare that to New York, “where Robin Wright is a tasteful example of over 40,” says derm David Colbert, who has star clientele on both coasts. Wright, 49, now a New Yorker, admitted to “just the tiniest sprinkle of Botox twice a year. Most women do 10 units, which freezes the face; I do one.” Adds Colbert, “Women in New York tell me they don’t want to look like they’re ‘from Los Angeles.’ ” Even Dr. Larry Koplin, a top Beverly Hills surgeon, agrees: “You don’t see any Michael Jackson types or trout mouths in New York. They do a better job making people less exaggerated and cartoony. In L.A., that’s what patients ask for.”   New York plastic surgeon Gerald Imber comments on the “different gestalts” of the two cities: From the consultation rooms to the attitudes of the doctors, “we are influenced by environment.” As such, the goals of appearance are very different. “New York women want a tougher face,” says Beverly Hills dermatologist Ava Shamban. “It’s slightly more masculine: a stronger chin, jaw and nose. In L.A., it’s more of a sweet, feminine face: a bigger lip and more slender noses. The standards of beauty relate to the values of the city.” In other words, one town’s known for celebrity and sex while the other celebrates power and money. With New York more resistant to youth culture, face-lift patients start older, notes Imber. “The standards are pretty different: In New York, a 50-year-old woman can be the hottest woman in the room.” Shamban sums up the age differentiation: “In New York, women want to look 40; in L.A., 20.” For either city, there’s also a practical consideration, says Peggy Siegal, the New York PR doyenne who discussed her two face-lifts (with Dr. Imber) in a pamphlet she handed out at her 60th birthday party, How to Look Like Me at 60: “Older women face age discrimination in the job market. Stopping the clock to a degree is the best way of eradicating that.” The East Coast may have its subtlety, but the West Coast has expertise. While the same procedures are popular in both cities — fillers, Botox, face- and eye-lifts — L.A. is ahead of New York in perfecting fat transfers and laser resurfacing. “In L.A., we don’t just think about pulling,” says Beverly Hills derm Peter Kopelson. “We think about replacing lost volume — and the people who are best at fillers are the ones who apply them most often.” Registered nurse Jamie Sherrill, known as Nurse Jamie to her A-list clients, adds that subtlety is on the rise in Hollywood and deploys what she calls “baby Botox”: “My ‘Gucci’ needle allows for only one drop. There’s a much more natural result.” She also says New York patients are more incremental and cautious, paying for consultations, then coming back for Botox, then returning for fillers, “so they pay a lot more money.” A brief survey among top doctors reveals that procedures in L.A. are about 30 percent lower in price (Botox from $900 in L.A. for 40-plus units to smooth out forehead, frown lines and crow’s feet versus $1,200 in New York; L.A. eyelid lifts start at $3,500, New York’s $5,000), but L.A. patients receive twice as many filler, laser and Botox treatments as New Yorkers. Skin appearance is prized differently, too, says Shamban: “In New York, while they dress beautifully, they often have bad or uneven skin. And they drink too much. In L.A., the women have softer and clearer skin due to the weather.” And almost every doctor conceded that “in L.A., there’s a tradition of seeing a perfection that no one can achieve,” to quote Imber. What that perfection really means is symmetry, as in Leonardo da Vinci’s Golden Ratio: an equation mathematicians have found in everything the human eye finds beautiful. Dr. Kopelson, for one, has no problem with that: “So women in L.A. are chasing perfection. But you have to admit, they get much closer to it than women anywhere else.”

Get The Facts On Gynecomastia

April 14th, 2015

Gynecomastia is the presence of excess fat and/or breast tissue in boys and men. It may affect either or both breasts. It is most widely prevalent in older men, newborns, and boys undergoing puberty.

Causes Of Gynecomastia

The common causes of gynecomastia are as follows.

  • Hormones: Natural hormonal imbalances in the body can lead to breast enlargement. Both men and women produce estrogen and testosterone in their bodies. Estrogen is responsible for female secondary sex characters whereas testosterone gives male ones. Over 50 percent of male infants have gynecomastia because of the high estrogen levels in their mother’s body. This subsides in a few weeks. During puberty, hormone imbalances can lead to this condition. Again, it goes away on its own within a couple of years. Gynecomastia, however, is quite common in older men (in the age group of 50 to 80 years) because the testosterone levels start reducing with age.
  • Medications: Apart from natural hormone imbalances, several medications can also cause gynecomastia. Antidepressants, anti-anxiety medications, medications used to treat prostate cancer and prostate enlargement, among others, can also lead to this condition.
  • Health issues: Aging, kidney and liver problems, malnutrition, hyperthyroidism and hypogonadism can all cause gynecomastia.

Treatment For Gynecomastia

Breast reduction surgeries can help reverse the enlarged breasts caused by gynecomastia. The surgery is conducted under general anesthesia and can take between 1 and 3 hours. Depending on the extent of the condition, different techniques can be used. If the primary problem is excessive fat, then liposuction can be a solution. It involves sucking out excess fat through tiny incisions. If there is excessive glandular tissue, then it will have to be cut out. Any excess skin that remains can be removed.

After the surgery, you may experience discomfort in the form of swelling and bruising. Medication can be prescribed, if necessary. You can return to work in a week’s time. But, for several weeks, you may be required to use elastic pressure garments. You will have to avoid strenuous physical activities for about a month.

Interested In Learning More About Male Breast Reduction? Contact Naples Cosmetic Surgery Center

To learn more about any of the procedures we offer, contact us today to schedule an appointment. Our offices are located in Naples, and we can be reached at 239-348-4357. We look forward to hearing from you.

What To Expect From A Body Lift

March 30th, 2015

Drastically losing pounds to reach a healthier weight is a huge accomplishment. Unfortunately, there are some challenges that come with serious weight loss. For instance, you probably have a lot of unnecessary extra skin. Depending on your genetics, age, and weight distribution, you may need surgery to remove the excess. To take care of the extra skin, a simple tummy tuck may not be enough, though. You may need a full body lift.

Body Lift Procedure: What To Know

  • Several Surgeries: In some instances, doctors perform a full body lift in one session. This can be quite risky and traumatic, though, so it’s more likely that your body lift will actually be a series of surgeries. The procedures you need will depend entirely on where the excess skin on your body is located. Many people who have lost extreme amounts of weight end up having some combination of an arm lift, a breast lift, a tummy tuck, and a lower body lift.
  • Lower Risk of Infection and Skin Chafing: Without all of that extra skin, your body is also likely to be healthier. When you have excess skin, especially flaps of it, you are at greater risk of getting infections because moisture, for example, can easily be trapped under the skin. You may also have had the excess skin chafe painfully against your functional skin. The removal of that unnecessary skin lowers such risks and discomfort.
  • Improved Appearances: After your surgery (or surgeries) you will find your skin more taut and even, with virtually no flab. With the excess skin and fat removed, you may feel more confident and enjoy your appearance more.
  • Scarring: Of course, the extensive surgeries included in a body lift can leave some scarring. Surgeons do their best to make incisions and tuck the skin in such a way that the scars will be hidden beneath commonly covered areas of the body, like under the arms, near the buttocks, or just below the waistline.

Want To Learn More About Body Contouring Options? Contact Naples Cosmetic Surgery Center

To learn more about any of the procedures we offer, contact us today to schedule an appointment. Our offices are located in Naples, and we can be reached at 239-348-4357. We look forward to hearing from you.

Do you want bright and radiant skin?

March 18th, 2015

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